RxPonder Changes the Field for Premenopausal Breast Cancer Patients With Involved Nodes

Attention must be paid to this large study that showed a substantial 5-year benefit from adding chemotherapy to the surgery, radiation and standard endocrine therapy (ET) given to premenopausal women with 1 to 3 involved axillary nodes and Oncotype Dx recurrence scores (RS) less than 26.¹ The 2.9% absolute reduction in distant metastasis as first events at about 5 years is important. The early 1.3% absolute reduction in deaths is important because