Not only is stem cell signaling in head and neck squamous cell carcinoma (HNSCC) an important component of the HNSCC response to DNA damage, but this signaling also may drive the repopulation response of HNSCC tumors, according to a team of investigators from several U.S. institutions.
Their findings, published in Stem Cells International (2016;2016:1894782. doi: 10.1155/2016/1894782, PMID: 26880935), suggest that targeting this mechanism may impede the ability of HNSCC tumors to