CHICAGO—Of several potential advances in the treatment of gastrointestinal cancers presented at the 2023 annual meeting of the American Society of Clinical Oncology, four new trials may help change the way several gastrointestinal (GI) cancers are treated. In two trials, investigators looked at approaches to personalize surgery treatment plans for colon and pancreatic cancers. Two other trials evaluated targeted therapies for HER2-positive biliary tract and colorectal cancers, but