Localized tumors from men with deleterious BRCA2 mutations were genetically more similar to metastatic cancer than to localized sporadic cancer in a study by investigators in Australia and Canada.
These findings of genomic and epigenomic patterns that may be responsible for the increased aggressiveness of germline BRCA2-mutant prostate cancers mark an important step forward at a time when the fields of urology and genitourinary oncology are beginning to turn to genetic