Depriving Ewing sarcoma cells of blood or oxygen leads to cell migration and increased invasiveness, investigators report (Neoplasia 2016;18:480-488)[CE:I could not find PMID]. These “microenvironmental stresses” prompted enhanced cell migration and an improved ability to invade a laboratory material resembling the complex extracellular environment found in tissues
“Clinically, these are very relevant stresses, as with upfront therapy (chemotherapy, radiation, or