The washout period between the last dose of metronidazole and the first dose of the alkylating agent busulfan can be reduced from seven to three days, according to research from The University of Texas MD Anderson Cancer Center, in Houston.
Busulfan, frequently used as part of conditioning for hematopoietic cell transplantation (HCT), has a well-established drug–drug interaction with metronidazole, which suppresses busulfan clearance and boosts treatment-related toxicity, the investigators