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FEBRUARY 14, 2017

Lenalidomide Maintenance May Extend PFS in CLL

Positive results seen in two trials, but expert predicts BCR pathway inhibitors may limit lenalidomide’s role in early maintenance

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San Diego—Lenalidomide maintenance extended progression-free survival (PFS) after first-line therapy in high-risk chronic lymphocytic leukemia (CLL) patients and after second-line therapy in CLL patients with at least a partial response to their last regimen, during two Phase III studies. Both trials were stopped early by their data and safety monitoring committees because of the large advantage of lenalidomide maintenance at an interim analysis.

In the trial evaluating lenalidomide