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APRIL 12, 2022

Darolutamide Triplet Therapy Improves Survival In mHSPC

Adding the androgen receptor inhibitor darolutamide (Nubeqa, Bayer/Orion) to androgen deprivation therapy (ADT) and chemotherapy prolongs the survival of men with metastatic hormone-sensitive prostate cancer (mHSPC), results from a new trial show.

Data from the global randomized, phase 3 ARASENS trial demonstrate that patients assigned to darolutamide plus ADT and docetaxel had a 32.5% lower risk for death compared with men assigned to placebo plus ADT and docetaxel. The reduction corresponds to