San Antonio—Although menopausal symptoms play a role in adherence to tamoxifen, the strength of the association between menopausal symptoms and adherence was similar in women assigned to placebo and those assigned to tamoxifen during a large, placebo-controlled trial by investigators from the United Kingdom and Australia.
Data from the International Breast Cancer Intervention Study I (IBIS-I) involving 3,987 women, showed that 71.5% of women in the placebo arm adhered to treatment for at